Leptin Hormone

What You Probably Knew

The Leptin hormone is a recently discovered hormone. It is well known for its role in hunger and energy balance. Leptin is released by happy fat cells when they are full. This signals the brain not to respond to Ghrelin, the hunger hormone. Up until the discovery of Leptin people (even me) thought that fat cells we just storage cells, not used for anything or certainly not an endocrine organ.

What you probably didn’t know is leptin is produced by multiple parts of the body and has receptors in other areas than just the hypothalamus!

Science!

A gene was discovered that when absent, mice ate voraciously and got super fat. This gene db, encodes for the leptin receptor on the hypothalamus. Thus if your born without this gene you don’t transcribe or translate the receptor and thus there is no where for leptin to bind and Ghrelin acts unopposed. Thus it’s clear that Leptin binding to the leptin receptor on the hypothalamus inhibits voracious eating. There are 8 mutations to the Ob(Lep) gene. It’s located on Chromosome 7 and the most recept mutation was discovered in 2015. All mutations cause this receptor not to bind Leptin and the subjects are incredibly obese from voracious eating.

Now the key to helping people resist overeating would be to either:
1) Increase natural Leptin production
2) Increase leptin receptor density on the hypothalamus
3) Administer a leptin supplement/Prohormone
4) Decrease ghrelin release
5) Decrease ghrelin receptor density
6) Administer a ghrelin receptor blocker

Now 4, 5, and 6 suck because we need the Ghrelin receptor to get maximal Growth Hormone release, and it’s the binding site for the Marus Alba in Wyked 2.1, Rise and Swell, and Nocturnus to give your along with Kudzu binding to the GHRH receptor 3 distinct mounting synergistic growth hormone spikes which keep you burning fat all day long. and of course Growth Hormone slows aging, for those of you who want to age as slow as I do.

The illegal drug family that bind to this site are the GHRP family. Read my incomplete guide on Growth Hormone Secretogogues here!

Leptin is not only produced in Adipocytes!

Leptin is produced primarily in the adipocytes of white adipose tissue. It also is produced by brown adipose tissue, placenta, ovaries, skeletal muscle, stomach (the lower part of the fundic glands and gastric chief cells), mammary epithelial cells, bone marrow, pituitary, and liver.
How Leptin Makes You Less Fat

Leptin Levels fluctuate wildly with different body fat levels. As body fat increases the leptin levels increase exponentially. This is noticed by bodybuilders post contest. For a week or so you simply can’t eat enough junk food, then eventually when your at about your set weight or set body fat % (which I think is a more accurate term than set weight) you are no longer hungry.

Leptin levels are quite high during the second half of sleep. This likely prevents you from waking up in the middle of the night hungry when your insulin levels are the lowest and you’re burning a great deal of fat. Obese people with obstructive sleep apnea produce less leptin overnight than those with a Cpap (positive airway pressure) machine. This implies that getting a good night sleep is necessary for fat regulation and appetite suppression. This confirms the urban legend that you need 6 continuous hours of sleep to get leptin release, and those who don’t gain body fat over time due to increased appetite through the next day.

Leptin is increased by insulin which makes sense, if your body is storing fat there would be no reason to be hungry.

Just like ghrelin makes you target high calorie foods, Leptin allows you to resist those high calorie foods and make wiser choices. Leptin levels in the short term have more to do with calorie intake levels then actual amount of body fat. Thus diets higher in calories and higher in actual exercise are emotionally less difficult than a low exercise, low calorie diet. The lack of calorie intake causes leptin levels to decrease allowing Ghrelin to push you into eating more fattening foods. And I for one feel guilty as fuck when I cheat on my diet. Ok, not that guilty. Like I almost stepped on a worm guilty. Not ran over a racoon guilty. Poor racoon:(

Leptin doesn’t just act on the brain to adjust hunger, it also acts on multiple tissues in the body to regulate energy metabolism and all hormones, namely Insulin, Glucagon, Growth Hormone, Insulin like Growth Factor 1 (IGF-1) and glucocorticoids like cortisol.

Read more about the Leptin hormone over at mindandmuscle.com!