Letrozole : King Of The Aromatase Inhibitors

If there is only one drug you use to boost your testosterone naturally it should be the breast cancer drug Letrozole (Femara). In a dutch study, Obese men with low testosterone and high estrogen were given just one 2.5mg dose per week with absolutely amazing results:



After just 6 weeks, LH, and FSH were more than doubled! This means Letrozole acts on the brain to increase the pituitary’s output of the hormones that signal the testes to produce sperm and testosterone.

Not surprisingly testosterone was increased, however it was quadrupled! thats Incredible! Obviously Estrogen was reduced as this is an Aromatase inhibitor and it was engineered to reduce estrogen. But no other Aromatase inhibitor or testosterone booster has had such dramatic effects. All told there was a tenfold reduction in the Estrogen:testosterone ratio.

The best part: the effects were almost as strong 6 months later.

In a Turkish study 2.5 mg were administered daily and surprisingly there was no increase to FSH and LH. additionally testosterone was only doubled, not quadrupled.



The estradiol level was reduced to half as it was in the once a week dosing study, so the final reduction in E:T ratio was only 5x.

Take home point is 2.5 daily counterintuitively does not work as well as 2.5 a week. My opinion is since the compound has a 3 day half life you're better off having 1 mg every 3 days for maximal T:E ratio!

For more info on how to restore normal function post cycle or just boost your natural testosterone click here!

[Fertil Steril. 2009 Aug;92(2):829.e1-2.]

Fertil Steril. 2010 Oct 8. [Epub ahead of print]

Eur J Endocrinol. 2008 May;158(5):741-7.

The Real Deal on Agmatine Sulfate

By Todd Lee M.D.

Im sure you've noticed all the new pre workout pump products have Agmatine sulfate in them now right? What you've probably heard is that it may or may not give a pump. Well it is a very confusing subject but I will make it easy. there are three versions of Nitric Oxide Synthase that Agmatine acts on. It inhibits the ones in your brain and heart, and activates the ones in your muscle capillaries. This means that Agmatine sulfate activates the enzyme that converts your traditional citruline and arginine based pump products into active nitric oxide in your muscle, but not elsewhere. Agmatine Sulfate amplifies the other pump products effectivenes!

The best time to take it isn’t pre-workout though, its first thing in the AM on an empty stomach. This also takes advantage of its growth hormone boosting effects. The pump benefit may take as much as 2 weeks to reach full effect but you will have an all day basal pump and pre workout Arginine will boost it to skin splitting levels!

Read the full article here!

Keto Diet: Carb-Free Dieting

By Todd Lee M.D.

0 carbs ever! Are you crazy? Well actually, yes. Yes I am. The Keto diet is sweeping the nation and for a good reason. It’s amazing in what it can do. Unlike previous 0 carb diets, the keto diet helps your body make particular molecules called ketone bodies from fat which fuel your brain. The brain is run almost exclusively on carbohydrates, but the rise and fall of blood sugar results in mood and energy fluctuations and disturbances. With the Keto diet, fuel is constant and steady so mood and energy are as well. Your body runs like a perfect machine and uses your body fat for fuel after a 2-6 week keto adaptation period. The trick is 80% of your calories come from fat! I know right! That sounds ridiculous, but it’s why all other 0 carb diets have failed in the past. By having a moderate amount of protein the liver you just convert your protein into carbs and you never convert over to Ketosis. If you want endless energy, to burn fat, and to be as healthy as humanly possible the keto diet is for you!

For more details click here!

Best Prohormones 2014

Dr. Todd Lee gives us his insights on this years best and worst prohormones!