After just 6 weeks, LH, and FSH were more than doubled! This means Letrozole acts on the brain to increase the pituitary’s output of the hormones that signal the testes to produce sperm and testosterone.
Not surprisingly testosterone was increased, however it was quadrupled! thats Incredible! Obviously Estrogen was reduced as this is an Aromatase inhibitor and it was engineered to reduce estrogen. But no other Aromatase inhibitor or testosterone booster has had such dramatic effects. All told there was a tenfold reduction in the Estrogen:testosterone ratio.
The best part: the effects were almost as strong 6 months later.
In a Turkish study 2.5 mg were administered daily and surprisingly there was no increase to FSH and LH. additionally testosterone was only doubled, not quadrupled.
The estradiol level was reduced to half as it was in the once a week dosing study, so the final reduction in E:T ratio was only 5x.
Take home point is 2.5 daily counterintuitively does not work as well as 2.5 a week. My opinion is since the compound has a 3 day half life your better off having 1 mg every 3 days for maximal T:E ratio!
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